We partner with you to create a project that meets your scientific and drug development needs.
- Jointly we will tease out sufficient detail to achieve your ultimate goals.
- We will make suggestions on how to contain costs, such as bundling your assays by testing multiple samples at one time, thus requiring fewer assays.
- We will discuss how to enhance the precision and accuracy of the assay.
- We will establish the format and level of detail needed in your report will be set to meet your project needs.
- Provide a price and provide time-line of your project in a formal bid.
- Once our bid is accepted, we will assign staff and get started!!
After the project is initiated, the typical course of events will start with samples being shipped to Marin Biologic. From there…
- You inform us when to expect the sample.
- For GLP & GMP projects, a chain of custody form will be submitted with Certificates of Analysis and a list of all the samples.
- The samples will be logged in to provide traceability and stored at the required temperature.
- A project manager/scientist will be assigned to your project and will frequently communicate the progress of the project.
As decisions are made during the course of a project you will be kept informed of progress. You dial in how informed you want to be on each project. For example, on very complicated experiments we can transmit the data after every experiment. Or, if you want to be less involved, we will make sound scientific judgments as the project progresses and just keep you in-formed. If we are waiting to expand cells or waiting for reagents we will of course provide you with an up-date.
At the conclusion of the project a final report will be submitted for your review, as per the original proposal. Should additional reporting be required, we can always accommodate such requests. Your report will be submitted electronically, except for GLP/GMP projects where they are submitted in writing.
Our scientists at MBL are here to facilitate your comprehension of the data and report. It is difficult to know all the innuendos when you are not designing plate maps and dilution schemes yourself. If your level of involvement is at this level we will be happy to accommodate this degree of interaction. On the other hand, if you wish to be apprised of the results only, we will gladly send data and summarize the results for you too.
At the conclusion of the project if you need further assistance, we will be happy to provide it. In those cases where we are called up to represent our client in data discussions with the FDA, know that we observe strict confidentiality and formality in those situations.
Because of our high Ph.D. to research assistant ratio, 1:2, Marin Biologic is able to successfully complete complex projects. We have Ph.D. expertise that spans the area of cell biology, biochemistry, molecular biology, and immunology. This enables our experienced scientist to work with complex biomolecules, to be cognizant of solubility and stability including -thaw and other methods to ensure no change in reactivity during transit from clinical cites to a central testing lab such as Marin Biologic.
Assay development performed at Marin Biologic includes a wide variety of assays, whether cell-based receptor binding or other modalities of activity (e.g. cell signaling), interaction with biomolecules, effective concentration and potency determination.
We routinely perform inhibition of enhancement generate cGMP cell banks for future use. Some assays have included receptor binding in membranes of cells, equilibrium dialysis, phosphorylation or receptor, adsorption onto substratum or serum proteins, or activation of immune cells.
We have phlebotomists on call to help us obtain white blood cells. We have cloned difficult DNA sequences that are large and optimized expression and restabilized (refolded) those found in inclusion bodies. We have purified protein to homogeneity.
Since our scientists are experienced PhD’s, working with experienced research associates, we can efficiently and successfully take your project to completion.