In Vitro Toxicology Overview
Marin Biologic performs a variety of in vitro toxicity tests and assays. We offer a number of assays performed under strict GLP and GMP compli-ance with FDA and EPA guidelines. and biochemical techniques.
Apoptosis You may want to know whether your drug candidates demonstrate cytotoxicity through apoptosis or necrosis.
We will measure different parameters for apoptosis compared to necrosis. We will discuss with you parameters such as drug concentration, time of exposure, measurement of DNA fragmentation in order to customize your in vitro cytotoxicity assay.
Cell Growth Another measure of cytotoxicity is the inhibition of cell growth or proliferation. No one mechanism may be responsible for this observation, however, proliferation rates can be measured as a response to drug concentration.
Some drugs may have a threshold level rather than a linear response for inhibition of cell growth. We will discuss parameters such as optimal target cell line, drug concentration, drug exposure time and drug delivery to customize your in vitro cytotoxicity assay.
- Cr51 Release
- Protein Metabolism
- DNA Synthesis
- RNA Synthesis
- Dose Range-Finding Investigation
- Plaque Titering Assay
- Cell Cycle Kinetics